ANNIHILATION Teaser Trailer Don’t miss the first ANNIHILATION teaser trailer! The film, directed by Alex Garland (Ex Machina), stars Natalie Portman, Jennifer Jason Leigh, Oscar Isaac, Gina Rodriguez, Benedict Wong, and Tessa Thompson. ANNIHILATION will be released in theaters on February 23, 2018. A biologist signs up for a dangerous, secret expedition where the laws of nature don’t apply.