Official ANNIHILATION Trailer Watch the official ANNIHILATION trailer! The film, directed by Alex Garland (Ex Machina), stars Natalie Portman, Jennifer Jason Leigh, Oscar Isaac, Gina Rodriguez, Benedict Wong, and Tessa Thompson. ANNIHILATION will be released in theaters on February 23, 2018. A biologist’s husband disappears. She puts her name forward for an expedition into an environmental disaster zone, but does not find what she’s expecting. The expedition team is made up of the biologist, an anthropologist, a psychologist, a surveyor, and a linguist.