PATIENT ZERO Trailer Debut Don’t miss the first PATIENT ZERO trailer! The film, directed by Stefan Ruzowitzky (The Counterfeiters), stars Natalie Dormer, Stanley Tucci, and Matt Smith. PATIENT ZERO will be released in theaters on September 14. In the pandemic thriller, Patient Zero, humanity is battling intelligent, adrenaline-fueled creatures born from a viral super-strain. After being bitten, human survivor Morgan (Matt Smith) realizes he is asymptomatic and can communicate with the infected, leading the last survivors on a hunt for Patient Zero and a cure.